Abstract: In order to explore the protective effects of Qishen oral solution on immunosuppressed mice, Qishen oral solution was ingested to mice whose immunity function was depressed by cyclophosphamide. Thymus index, spleen index, the serum level of hemolysin, the serum content of IL-2 and phagocytic index of reticuloendothelial cell were measured. The results showed that Qishen oral solution could significantly increased thymus index, spleen index, the serum level of hemolysin, and phagocytic index of reticuloendothelial cell in immunosuppressed mice (P<0.01). In conclusion, Qishen oral solution possessed the protective effects on immunosuppressed mice.