Abstract: In order to research the enzyme activities and contents of active materials, which were involved in anti-oxidation capability of tissues, were investigated in Amur sturgeon (Acipenser schrencki Brandt.) when oral given the prescription of Traditional Chinese Medicine A. The immune function of prescription A on sturgeons was also studied under high temperature stress condition. 1+ age old fish were divided into 2 groups each (n=60 in each group), with each group subdivide into 3 replicates of 20 fish per tank. A control group, in which distilled water was administered orally, was also tested. Prescription A was orally given to experimental fish at a concentration of 1.1 g/kg body weight continuously for 7 days. After the administration of drugs, parts of fish were stimulated for 2 hours at high temperature (30℃) and samples were collected. Superoxide Dismutase (SOD) activity in plasma, liver and red blood cells, Malondialdehyde (MDA) and Nitric Oxide (NO) content in plasma and liver, and Nitric Oxide Synthase (NOS) activity in plasma and liver, were measured and compared. The results indicate that prescription A could efficiently regulate NO content and NOS activity, increase SOD activity and decrease MDA content in several tissues of Amur sturgeon. The prescription A also brought better effects to protect the body from oxidative damage under the thermal stimulation. Thus, the prescription A was a suitable Traditional Chinese Medicine for sturgeon farming as an immune additive since it still had fine effect under the high temperature stress condition.