Abstract: Land use division can reflect the regional variance in land and is an important aspect of comprehensive land use planning. The aim of this paper is to provide theoretical direction for land use and the future development of coastal region in prefecture in hilly southwestern of China. Taking Jiangjin prefecture in Chongqing as the example, creating a division system of land use rationalization, assigned the appraisal index system and standardized the statistics. The quantification of the land use in Jiangjin was classified based on the hierarchical cluster analysis of SPSS. In order to satisfy the boundary completion of region, the regional continuity as well as the demands for future economic development, the study made future adjustments depending on the classification results. The region, it was divided into three sub-regions: highly development area in the northern town, potential development in middle area, agroforestrial ecotope in southern. At last, the main problems and future development direction in landuse for each sub-regions were put forward according to the similarity and discrepancy among different regions. Finally, the result indicated that cluster analysis could use to land use regionalization of prefecture in hilly southwestern. Meanwhile, it is a beneficial change from quality to quantify.