Abstract: The effects of improvement soil by application sand on growth development, yield and quality of flue-cured tobacco on the heavy clay soil were Studied. The results showed that the treatments of application sand 2 kilogram,3 kilogram,4 kilogram per plant separately on agronomic characters were better than that of application sand 1 kilogram and the control on the heavy clay soil. The yield, quality, average price and superior leaf ratio of flue-cured tobacco were increased significantly. The content of reducing sugar, total sugar and potassium were better by application sand 3 kilogram and 4 kilogram per plant separately than that of application sand 1 kilogram, 2 kilogram and the control, but the content of nicotine was decreased, but the effects of chemical composition by application sand1 kilogram,2 kilogram per plant separately were not marked.