Abstract: In order to investigate the resistance characteristics of Minxinan Black Rabbit, the humoral immunity and cellular immunity indicators were measured, which could evaluate Minxinan Black Rabbit immunity comprehensively and systematacially, and that also indirectly reflect the non-specific resistance characteristics. In this paper, the content of immunoglobulin IgG, IgM, IgA and complement C3, C4 in Minxinan Black Rabbit’s (90 days, 12 male and 12 female) serum were determinated, the change of the peripheral blood lymphocyte transformation and the phagocytosis ability of neutrophil were tested. The results showed that,the content of immunoglobulin IgG, IgM, IgA on Minxinan Black Rabbit were 2031.22 mg/L, 96.78 mg/L, 10.94 mg/L, complement C3, C4 were 55.15mg/L, 17.89 mg/L, lymphocyte stimulation index was 1.50 ， neutrophil phagocytic rate was 58.39% and neutrophil phagocytic index is 2.22. IgG, IgM, IgA , C3, C4 has no significant difference between sex (P>0.05). The immune indexes may provide a reference in general resistance selection and nonspecific resistance breeding.