Abstract: The field research was conducted to study the optimum density for large- scale mechanized operations, and to obtain high yield cultivation techniques of red-seed watermelon in field production. The experiments used a factorial arrangement of different density 3700, 5550, 7400 per 667 m² with expansion of row. The yield and quality was highest with density of 5550 per 667 m², its yield reached 147.8 kg/667 m², and was significantly different from other treatments. Therefore, the optimum density for red-seed watermelon was 5550 per 667 m² in Changji area, and its growth, the main economic character, yield, dry matter accumulation was the best.