Abstract: 24 male mice were divided into four groups randomly, different concentrations of formaldehyde and saline solution were taken by intraperitoneal injection. Then the coefficient ofSliver and kidney, the content of malondialdehyde (MDA) and glutathione (GSH) were detected. Our results detected that the coefficient of liver and kidney in mice were not changed significantly by different doses of formaldehyde (p＞0.05). The content of MDA was increased significantly(p＜0.05)and the content of GSH was decreased not significantly (p＞0.05) in livers by formaldehyde of 10 and 100 mg/kg. The content of MDA was increased and the content of GSH was decreased not significantly in kidneys by different concentrations of formaldehyde (p＞0.05). All results shown that different concentrations of formaldehyde were taken by intraperitoneal injection in mice could induced oxidative damage significantly and related to the dose of formaldehyde in livers of mice. However, the kidney of mice were not changed obviously.