Abstract: In order to solve side effect of long-term application of inorganic fertilizers on quality and yield of vegetables and soil fertility, in this study, pot experiments and field trials are used to research the influences of biological-organic-inorganic compound fertilizer on growth and yield of cabbage. The results showed that, adding strain Y2 or Y2 and metabolite X-N to the organic-inorganic compound fertilizer N-P₂O₅-K₂O of 16-6-8 formula which contained tobacco stems and tobacco powder could achieve the best effect, and whole weight reached 213.333 and 200.000 g respectively after 45 days. Compared with single application of organic-inorganic fertilizer 16-6-8 with tobacco powder, the cabbage weight increased by 26.73% and 18.81%, and the difference was not significant. The overall effect was poor after adding G2 and metabolites and the difference was not significant. After adding Y2 and metabolites X-N, the effect of the organic-inorganic fertilizer of 16-6-8 formula containing oil cake was the best, the single plant weight reached 196.667 g, increased by 25.53% compared with that which had no adding agents. Overall, the mixed use the Y2 strain and metabolite A-N could not improve the fertilizer efficiency, but also inhibited the growth of crops. When Y2, G2, X-N and A-N were used together, the effect was not good and could not achieve the growth-promoting effect, and finally inhibited plant growth. The results of field trial and pot experiment were consistent.