Abstract: This experiment was conducted to investigate the effect of Lactobacillus plantarum P-8 on the growth performance, fecal pH and content of indole and skatole, lincomycin hydrochloride residue of broilers in the scale breeding. 180000 one-day-old commercial broilers (Arbor Acres, AA) were randomly divided into three groups with 60000 chickens in each group. The chickens in the control group were fed the basal diet, and those in the two test groups (group 1 and group 2) were fed the basal diet and L. plantarum P-8. Lincomycin hydrochloride was added in the basal diet of three groups for 30 days and the addition was 3, 3 and 1.5 g/t for the control group, group 1 and group 2, respectively. The results showed that the survival rate, average weight and water consumption of the two test groups were significantly higher than that of the control group (P<0.05), the feed conversion ratio of the two test groups was significantly lower than that of the control group (P<0.05), there was no significant difference between the two test groups (P>0.05). The fecal pH and the content of indole and skatole in chicken fecal of the two test groups were significantly lower than that of the control group (P<0.05), and there was no significant difference between the two test groups (P>0.05). The lincomycin hydrochloride residue in chicken of the two test groups was significantly lower than that of the control group (P<0.01), and there was no significant difference between the two test groups (P>0.05). In conclusion, L. plantarum P-8 is advantageous in reducing the dosage of antibiotics and improving the growth performance and breeding environment in the scale broiler breeding, and it is of benefit to the sustained and healthy development of poultry breeding, and will have a wide application prospect.