Abstract: Industrialization, IT application, urbanization and agricultural modernization (referred to as“New Four Modernizations”) development are significant index to measure regional economic development. According to the mechanism of interaction among industrialization, IT application, urbanization and agricultural modernization, the author designed an index system of the development level of“New Four Modernizations”evaluation. By introducing relevant data of“New Four Modernizations”of 14 cities in Hunan Province, the author comprehensively evaluated the development of“New Four Modernizations”level in the 14 cities based on the entropy and the grey relational analysis. The study found that the development level of “New Four Modernizations”in the 14 cities was significantly uneven, there was "Matthew Effect", in which the strong one was getting to be stronger, and the weak one was going to be weaker. Therefore, we should further straighten out the four modernizations synchronous development, implement reformation and innovation in four aspects, including mechanism construction, urban- rural integration, interactive fusion and regional coordination, to promote the synchronous development of“New Four Modernizations”.