Abstract: To study the effect of myricetin on schizophrenia-like behavior of demyelinated mice, forty healthy male Kunming mice were randomly divided into 4 groups: the normal group, the model group, the myricetin group and the chlorpromazine group. The normal group was fed with normal mouse feed, while the other three groups were fed with feed that contained 0.2% (w/w) CPZ to construct demyelination. Once a day for 5 weeks, the myricetin group was intragastric administrated with 20 mg/kg myricetin, and the chlorpromazine group was intraperitoneal injected with 4 mg/kg chlorpromazine. Then changes in the behavior of mice were observed by behavioral examinations. LFB staining was conducted to display the degree of myelin damage. The results of behavioral examinations showed that, compared with the model group, mice in the myricetin group had significantly better behavioral indicators, and myricetin had almost the same therapeutic effect with chlorpromazine. LFB staining showed that the myricetin group had more compact myelin than the model group. In conclusion, myricetin has potential therapeutic effect toward schizophrenia-like behavior of mice caused by demyelination. This experiment offers a basis for the clinical application of myricetin.