Abstract: The purpose is to analyze the situation of ecological security in Gansu from 2005 to 2015 and predict its development trend, thus to provide reference for improving the ecological environment situation. Based on the driving force-pressure-state-response (DPSR) model, an evaluation index system of ecological security early warning of Gansu was established. Then, entropy method was used to analyze the ecological security situation from 2005 to 2015. Finally, the evolution trend of ecological security from 2018 to 2022 was predicted by grey GM (1,1) model. The results indicated that: the ecological security index of Gansu increased from 0.4103 to 0.5967 from 2005 to 2015 with a fluctuating increase trend, and the ecological security level was from Grade III to Grade II, and then turn to grade III, showing a“U”type trend, which indicated that the ecological environment of Gansu was improved to some extent after experiencing a deterioration. According to the results of the grey GM (1,1) model, the ecological safety index of 2018 to 2022 was 0.6344, 0.6592, 0.6859, 0.7148 and 0.7458, respectively, indicating that the ecological security situation in Gansu maintains a good momentum.