Abstract: The paper aims to study the optimal cropping pattern for water saving and high-yield cultivation of seed corn with drip irrigation under mulch in northwest arid region of China. We arranged 9 narrow and wide row spacing treatments, the narrow row spacing contained the treatments of 30 cm (N30) and 40 cm (N40); the wide row spacing contained 60 cm (W60), 70 cm (W70), 80 cm (W80), 90 cm (W90) and 100 cm (W100); thereinto, the plant spacing of N40 treatment with no wide row spacing 100 cm was 15 cm. The results showed that: when the narrow row spacing was the same, with the increase of wide row spacing, the plant height had a decreasing trend, while, the stem diameter and the leaf area index (LAI) increased gradually; under the same planting density, the stem diameter was small and the plant height was high when the narrow line spacing was 30 cm; the accumulative water consumption ET range of each treatment during growth period was about 525.10-545.18 mm; from the perspective of the total yield level, N30 treatment was higher than N40 treatment in the same planting density. From the perspective of stable and high yield, it is recommended that the local seed corn planting pattern with drip irrigation under mulch could be narrow planting spacing of 30 cm and wide-row planting spacing of 70 cm.