Abstract: The purpose is to explore the harvest stage, drying temperature, seed size and germination temperature of capsule of Mesembryanthemum crystallinum, and provide technical support for seedling breeding. Using the M. crystallinum capsules and seeds as materials, the effects of different harvest stages, capsule drying temperature, seed size and germination temperature on seed germination were studied. The results showed that the highest germination rate was obtained when the capsule turned to yellow and the water content was below 20%. The germination rate of brown capsule was the second, and that of the green capsule was the worst. The seed germination rate of 0.7-0.9 mm seeds was the highest, 82.3%. Drying of capsule showed that capsule dried at 40℃ for 5.5 h were easy to be crushed and threshed, the seed moisture content was below 7%, and the germination rate of seeds was above 89%. The seed germination rate at 25℃ was the highest, 83%. When the capsule turns yellow, it should be harvested, then dried at 40℃ for 5.5 h, and then treated with a 0.7-0.9 mm mesh sieve. The germination rate of the seeds treated by the above process is the highest. The optimum temperature of seed germination is 25℃.