Abstract: To provide scientific and technological support for the rational utilization of climate resources and the sustainable development of agricultural production in the south edge of the Qaidam Basin, using the data of temperature, accumulated temperature, sunshine duration and precipitation from 1961 to 2015, we analyzed the change features of agro-climatic resources by means of statistical methods such as climate tendency rate and coefficient. The results showed that (1) the heat resources presented an increasing trend, both annual and seasonal average temperature increased obviously, the annual average temperature variation tendency rate was 0.49℃/10 a; ≥0℃ and ≥10℃ annual accumulated temperature variation tendency rate was 77.0℃/10 a and 102.5℃/10 a, respectively; (2) the light resource reduced a bit, the decrease tendency rate of the annual average sunshine duration was 35.2 h/10 a, meanwhile that of summer decreased significantly by 16.7 h/10 a; (3) the precipitation resources showed a slightly increasing trend, the increase tendency rate of annual precipitation was 6.0 mm/10 a, obviously in summer with the rate of 4.0 mm/10 a; (4) the change of agroclimatic resources is beneficial to adjust the agricultural planting structure, develop facility and characteristic agriculture and increase yield; however, it could intensify the contradiction between water supply and demand in agriculture production, cause more crop diseases and pests, and increase agricultural cost and input.