Abstract: The authors used the mixed design method of three factors each having five levels , established the mathematical model of the fertilizer of N, P and K and the yield and profit of Glutinous maize. According to the mathematical model .(1) the effect of the fertilizer of N to the yield and profit is the most remarkable, P secondly and K thirdly.(2) The design of optimum application is N 6. 98～10.35㎏、P2O5 3.69～4.95㎏、K2O 5.81～8.22㎏, which can gain the yield more than 950㎏／667㎡and the profit more than 1000元／667㎡.