Abstract: [Objective] to study effect of bromocriptine mesilate on breeding performance of “Huizhouma”native hens. [Method] 40 birds (Huizhouma breeding hens) were allotted into trial group, other 588 birds were arranged to control group. The birds of trial group were administrated bromocriptine mesilate (1.25mg/bird/day) for 4 days, again using the drug interval 4 days; the birds of control group were no administrated drug. [Results] The result in 4 weeks showed that the laying rate of trial group and control group was 83.86%and 69.96% respectively; broken egg rate and malformed egg rate of trial group were 1.28% and 4.33%, that of control group was 1.69% and 1.19%; total egg number and hatchable egg number of trial hen were more than that of control hen 3.89 and 3.26 respectively ; average egg weight was not affected. E2 level in blood of trial group was higher than control group. [Conclusion] Synthesized and secreted of PRL and brooding hens was reduced, reproduce performance of native poultry was improved through administrate Bromocriptine mesilate.