Abstract: Abstract 【Objective】To clone and analysis the Oryctolagus cuniculus CCR10. 【Method】A pair of cloning primers were designed based on the in silico sequence information, Total RNA was extracted from intestinum caecum mucosal tissue of Oryctolagus cuniculus and mRNA sequence was amplified by RT-PCR. The PCR products were ligated into the pMD19-T vector, and then transformed into competent cells of E.coli JM109. The positive clone was identified and the sequence was sequenced and analysis. 【Results】Oryctolagus cuniculus CCR10 consists of 723bp and encodes 241 amino acids . Tertiary structure predicts that CCR10 contains a PIG-X domain. Identity analysis showed that the CCR10 nucleotide sequence shared 89.6%、89.9% homology with that of Oryctolagus cuniculus、Ovis aries、Homo sapiens, the predicted peptide shared 94.2%、93.8% homology with that of Oryctolagus cuniculus、Ovis aries、Homo sapiens. revealing that the structural feature is consistent with Oryctolagus cuniculus、Ovis aries、Homo sapiens CCR10.【Conclusion】The Oryctolagus cuniculus CCR10 gene was successfully cloned in present study and the sequence has been submitted to GenBank(Accession. EU348829).