Welcome to Chinese Agricultural Science Bulletin,

Chinese Agricultural Science Bulletin ›› 2014, Vol. 30 ›› Issue (31): 57-63.doi: 10.11924/j.issn.1000-6850.2014-1855

Special Issue: 生物技术 园艺 烟草种植与生产

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Research Advances in Tobacco Bioreactor for Production of Therapeutic Proteins

  

  • Received:2014-07-04 Revised:2014-07-04 Accepted:2014-08-08 Online:2014-11-20 Published:2014-11-20

Abstract: This article reviewed three main kinds of therapeutic proteins produced by tobacco bioreactors, concluded the expression systems producing exogenous recombinant protein including nuclear expression, chloroplast expression and transient expression, and highlighted oral tolerance induction using tobacco expressing autoantigens, accordingly this article raised the problems to be solved in tobacco bioreactor research and the solutions. From above analysis, prospect was made for further improvement of tobacco bioreactor for production of pharmaceutical proteins and its application in China's tobacco control programs.