Abstract: In order to obtain wheat varieties with high and stable yield, which are suitable for planting in Huaibei region of Jiangsu Province,‘Yannong No.19’was hybridized with‘Zhengzhou 991’in Agriculture Science Research Institute of Huaiyin in Xuzhou and Huaiyin area of Jiangsu Province in 2001,‘Huaimai No.33’was bred with pedigree method, and passed the Jiangsu provincial approval in 2013 (Jiangsu review of the 201305) and the national approval in 2014 (country review of the 2014001). The results showed that the average yield was 7977.90 kg/hm2 in regional trial of Jiangsu Province from 2010 to 2012. The yield increased by 6.28% compared with that of the control‘Huaimai No.20’. The average yield was 7948.95 kg/hm2 in production test of Jiangsu Province from 2012 to 2013. The yield increased by 5.96% compared with that of the control‘Huaimai No.20’, ranking the first among the tested varieties. The average yield was 7563.30 kg/hm2 in the national regional trial from 2011 to 2013, increased obviously by 6.83%, compared with the control ‘Zhoumai No.18’, the rate of production increase was 94.10%, the variation coefficient was10.11%, and the fitness was 82.34%. The average yield was 8934.00 kg/hm2 in national production test and 6.13% higher than that of‘Zhoumai No.18’(CK), ranking the first among the test varieties and the rate of production increase was 100%. The results showed that‘Huaimai No.33’was a new wheat variety of ideal plant type and high yield potential, it had good resistance and tolerance to diseases and adverse harm in Huanghuai area, and the variety maintained an obviously stable yield in wheat scab outbreaks of 2010 and 2012 and the unusually serious cold spell in late spring of 2013.