Abstract: The authors studied the response of summer maize to different N, P and K levels and nutrients balance use in Heilonggang valley. The results showed that: the yield of summer maize significantly increased under fertilizer application. The response of yield indicated that N was the first remarkable factor, K was second and P was third. With the increased application amount of NPK, the excess amounts of NPK in soil were increased. The fertilizer use efficiency of NPK was 10.0%- 31.6% , 13.3%- 23.3% and 52.5%- 60% , respectively. Based on comprehensive consideration of yield, nutrients balance and nutrient uptake and utilization, the N, P2O5 and K2O fertilizer rate should be 225-255 kg/hm2, 60-75 kg/hm2 and 120 kg/hm2, respectively.