Abstract:

Abstract:To research the effects of the water extract from Nerium indicun leaves on action potential of the toad’s sciatic nerves. The toad’s sciatic nerves were divided into three groups, and infiltration with concentration of 10％,20％and 40％of the water extract from Nerium indicum leaves. the amplitude, conduction velocity, threshold intensity and refractory period of action potentials of the sciatic nerves from each group were measured respectively by BL-420F organism function experiment system. The conclusion of study had indicated that the water extract from Nerium indicun leaves could decrease the conduction velocity (p<0.05),slowed down the conduction velocity (p＜0.05),extended the refractory period (p<0.05),and increase the threshold intensity(p＜0.05).The action potential of sciatic nerves vanished at last. The action potential of sciatic nerves could recover. The conclusion of study had indicated that the water extract from Nerium indicum leaves could block the conduction of action potential of nerve reversibly.