Abstract: This paper analyzed the average weight of 6 three-way crossbreeding combinations of beef cattle (XiaXiNan, XiXiaNan, LiXiaNan, XiaLiNan, LiXiNan and XiLiNan)at the age of 6, 12 and 18 moon from the six counties of four cities of Henan Province.The results showed that XiaXiNan, LiXiNan, XiXiaNan and XiLiNan four hybrid combinations were better than others, and in the process of three-way crossbreeding, the first father was meat-milk or milk-meat type bull that have maternity index; the second father was purebred meat type bull that grow faster and has good carcass quality, so that it could improve milk capability of reproduction cow and enhance growth rate, slaughter rate and carcass quality of beef cattle.