Research Progress of Chemical Constituents and Pharmacological Effects of Common Medicinal Plants of Ilex

doi:10.11924/j.issn.1000-6850.casb2023-0318

Abstract

Abstract:

Plants of Ilex have high medicinal value. They generally contain triterpenoids, flavonoids and other chemical components. They can reduce blood lipids, protect cardiovascular and cerebrovascular systems, and fight bacteria and inflammation in clinical practice. With the development of science and technology and the discovery of the medicinal value of Ilex, great progress has been made in the research of Ilex. This paper summarized the research progress of chemical constituents and pharmacological activities of commonly used medicinal plants of Ilex in recent years and put forward relevant suggestions, which would provide reference for the systematic research of Ilex in the future and facilitated the better utilization of resources.

Key words: Ilex, medicinal value, chemical composition, pharmacological activity

CHENG Gong, ZHANG Jianhong, YUAN Huwei, ZHENG Bingsong, YAN Daoliang. Research Progress of Chemical Constituents and Pharmacological Effects of Common Medicinal Plants of Ilex[J]. Chinese Agricultural Science Bulletin, 2024, 40(8): 30-37.

Figures/Tables 3

References 82

[1]	WU Z Y, RAVEN P. Flora of China[M]. Beijing & St Louis: science press & missouri botanical garden press, 2020:1994-2009.
[2]	曾沦江. 中国冬青科植物志资料[J]. 植物研究, 1981, 1(1-2):1-44.
[3]	李冬玲, 付晖, 任全进, 等. 中国华东地区冬青属药用植物资源调查[J]. 中国野生植物资源, 2003, 22(1):22-24.
[4]	何丹, 杜冰曌, 杨鑫瑶, 等. 冬青属常用药用植物的药理作用及临床应用研究进展[J]. 中国实验方剂学杂志, 2020, 26(16):218-227.
[5]	刘四君, 程齐来, 李洪亮. 冬青属药用植物研究进展[J]. 湖北农业科学, 2009, 48(10):2594-2597.
[6]	刘瑾, 丁平. 冬青属药用植物资源、化学成分及药理作用研究进展[J]. 广州中医药大学学报, 2008, 25(3):277-280.
[7]	陈伟祥, 王昌腾. 浙江冬青属药用植物资源及其利用[J]. 中国林副特产, 2005(6):52-53.
[8]	涂子月. 丽水市冬青属药用植物资源及其利用[J]. 安徽农学通报(下半月刊), 2012, 18(24):143-144.
[9]	LI LI, XU LI J, MA GUI Z, et al. The large-leaved Kudingcha (Ilex latifolia Thunb and Ilex kudingcha C.J. Tseng): a traditional Chinese tea with plentiful secondary metabolites and potential biological activities[J]. Journal of natural medicines, 2013, 67(3):425-437. doi: 10.1007/s11418-013-0758-z pmid: 23529541
[10]	韦晓洁, 银慧慧, 孟菲, 等. 苦丁茶有效成分及药理活性的研究进展[J]. 中国医药导报, 2017, 14(24):62-65.
[11]	解军波, 李萍. 冬青属植物化学成分及药理活性研究进展[J]. 中草药, 2002, 33(1):85-88.
[12]	祝晨蔯, 杨金燕, 林朝展. 冬青属植物化学成分及药理活性的研究进展[J]. 时珍国医国药, 2008, 19(3):759-762.
[13]	王存琴, 张艳华. 大叶冬青的化学成分及药理活性研究进展[J]. 中国药房, 2014, 25(11):1052-1054.
[14]	姚兰. 大叶冬青化学成分及其生物活性研究[D]. 吉林: 吉林农业大学, 2018.
[15]	方心睿, 王贯, 乔成, 等. 岗梅中的三萜皂苷类化合物[J]. 沈阳药科大学学报, 2018, 35(9):733-738.
[16]	ZHANG H X G, DU B Z, ZHAO FENG, et al. Three new triterpenoid saponins from the stems of Ilex asprella[J]. Journal of Asian natural products research, 2018, 20(5):439-444. doi: 10.1080/10286020.2018.1449836 URL
[17]	YANG ZHANG, BOWEN DENG, YIDA CUI, et al. Two new secoiridoid glucosides and a new lignan from the roots of Ilex pubescens.[J]. Journal of natural medicines, 2018, 72(4):946-953. doi: 10.1007/s11418-018-1227-5 pmid: 30046967
[18]	LI R F, XIA W Q, LIU J B, et al. New triterpenoid saponins from the leaves of Ilex chinensis[J]. Fitoterapia, 2018, 131:134-140. doi: 10.1016/j.fitote.2018.10.007 URL
[19]	YANG BAO, ZHU J P, RONG LI, et al. Triterpenoids with antiplatelet aggregation activity from Ilex rotunda[J]. Phytochemistry, 2018, 145:179-186. doi: S0031-9422(17)30352-7 pmid: 29169092
[20]	DU B Z, ZHAO FENG, ZHANG H X G, et al. Asprenols A-H, phenolic constituents from the stems of Ilex asprella[J]. Fitoterapia, 2018, 129:220-225. doi: S0367-326X(18)31013-X pmid: 30031114
[21]	XIA W Q, LI R F, LIU J B, et al. Triterpenoids from the leaves of Ilex chinensis[J]. Phytochemistry, 2018, 148:113-121. doi: 10.1016/j.phytochem.2018.01.008 URL
[22]	HUANG X J, WEN SI, GUAN X F, et al. Eleven New Triterpenoid Glycosides from the Roots of Ilex asprella.[J]. Chemistry & biodiversity, 2019, 16(7):e1900202.
[23]	LONG HUI, YAN Q F, HU Z H, et al. A new para-quinone-type flavan from the leaves of Ilex centrochinensis and its anti-inflammatory activities.[J]. Journal of Asian natural products research, 2019, 21(1):86-92. doi: 10.1080/10286020.2018.1453504 pmid: 30973279
[24]	ZHOU X D, XU X W, XI Y Y, et al. Terpenoid and phenolic constituents from the roots of Ilex pubescens[J]. Fitoterapia, 2019, 138(C):104298. doi: 10.1016/j.fitote.2019.104298 URL
[25]	冯海燕. 枸骨叶中抑制脂肪酶活性成分的快速识别与分离、鉴定[D]. 上海: 上海中医药大学, 2019.
[26]	石照宇. 大叶冬青、鹧鸪花和桃花心木的化学成分研究[D]. 天津: 南开大学, 2020.
[27]	Chemistry - Phytochemistry; Research conducted at Shanghai University of Traditional Chinese Medicine has updated our knowledge about phytochemistry (Anti-adipogenic 18,19-seco-ursane stereoisomers and oleane-type saponins from Ilex cornuta leaves)[J]. Chemicals & chemistry, 2020.
[28]	SHAO S Y, LI R, SUN HUA, et al. New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity[J]. Chinese journal of natural medicines, 2021, 19(5):376-384. doi: 10.1016/S1875-5364(21)60036-5 URL
[29]	KAKUMU YUYA, NGUYEN THI MINH TU, YAMAUCHI KOSEI, et al. New benzoic acid and caffeoyl derivatives with anti-inflammatory activities isolated from leaves of Ilex kaushue.[J]. Natural product research, 2021, 36(12):1-9. doi: 10.1080/14786419.2021.1939334 pmid: 34382490
[30]	彭收. 救必应和山乌桕的化学成分和药理活性研究[D]. 北京: 中国科学院大学(中国科学院上海药物研究所), 2022.
[31]	NAGATOMO AKIFUMI, INOUE NAOKI, KONNO TAKUYA, et al. Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.[J]. Journal of natural medicines, 2022, 76(3):654-669. doi: 10.1007/s11418-022-01614-5 pmid: 35292883
[32]	ZHANG WEN, CHEN S T, HE Q Y, et al. Asprellcosides B of Ilex asprella Inhibits Influenza A virus infection by blocking the Hemagglutinin- mediated membrane fusion.[J]. Frontiers in microbiology, 2018, 9:3325. doi: 10.3389/fmicb.2018.03325 URL
[33]	CUI M X, TIAN J Y, SUN JUN, et al. Isolation, Structural analysis and anti-inflammatory activity of a Polysaccharide from Ilex cornuta fruits[J]. Chemistry & biodiversity, 2022, 19(6):e202200084.
[34]	LI X X, YUAN R Y K, WANG Q Q, et al. Rotundic acid reduces LPS-induced acute lung injury in vitro and in vivo through regulating TLR4 dimer.[J]. Phytotherapy research: PTR, 2021, 35(8):4485-4498. doi: 10.1002/ptr.v35.8 URL
[35]	ZHAO W W, XIAO MENG, YANG JIE, et al. The combination of Ilexhainanoside D and ilexsaponin A 1 reduces liver inflammation and improves intestinal barrier function in mice with high-fat diet-induced non-alcoholic fatty liver disease[J]. Phytomedicine, 2019, 63(C):153039. doi: 10.1016/j.phymed.2019.153039 URL
[36]	WAN PENG, PENG Y J, CHEN G J, et al. Dicaffeoylquinic acids from Ilex kudingcha attenuate dextran sulfate sodium-induced colitis in C57BL/6 mice in association with the modulation of gut microbiota[J]. Journal of functional foods, 2019, 61(C):103468. doi: 10.1016/j.jff.2019.103468 URL
[37]	PENG WAN, MINHAO XIE, GUIJIE CHEN, et al. Anti-inflammatory effects of dicaffeoylquinic acids from Ilex kudingcha on lipopolysaccharide-treated RAW264.7 macrophages and potential mechanisms[J]. Food and chemical toxicology, 2019, 126:332-342. doi: S0278-6915(19)30011-0 pmid: 30654100
[38]	万鹏, 陈贵杰, 彭宇佳, 等. 冬青苦丁茶中二咖啡酰奎宁酸降低炎症水平并调节小鼠肠道菌群[C]//. 中国食品科学技术学会第十六届年会暨第十届中美食品业高层论坛论文摘要集, 2019:161-162.
[39]	XU XIAO, HUA H W, WANG L M, et al. Holly polyphenols alleviate intestinal inflammation and alter microbiota composition in lipopolysaccharide-challenged pigs[J]. British journal of nutrition, 2020, 123(8):881-891. doi: 10.1017/S0007114520000082 URL
[40]	CHEN GANG, HAN Y Q, FENG YUAN, et al. Extract of Ilex rotunda Thunb alleviates experimental colitis-associated cancer via suppressing inflammation-induced miR-31-5p/YAP overexpression[J]. Phytomedicine, 2019, 62:152941. doi: 10.1016/j.phymed.2019.152941 URL
[41]	YANG X Y, GAO X L, DU B Z, et al. Ilex asprella aqueous extracts exert in vivo anti-inflammatory effects by regulating the NF-κB, JAK2/STAT3, and MAPK signaling pathways[J]. Journal of ethnopharmacology, 2018, 225:234-243. doi: S0378-8741(18)31105-X pmid: 29981433
[42]	LI YAO, YANG XU, YUAN J N, et al. Ilex rotunda thunb protects against Dextran Sulfate Sodium-induced ulcerative colitis in mice by restoring the intestinal mucosal barrier and modulating the Oncostatin M/Oncostatin M receptor pathway[J]. Frontiers in pharmacology, 2022, 13:819826-819826. doi: 10.3389/fphar.2022.819826 URL
[43]	王莹, 陈冰莹, 伍钰蓉, 等. 基于转录组学研究毛冬青三萜皂苷对脂多糖诱导小鼠肠损伤的保护作用及其机制[J]. 中草药, 2022, 53(22):7102-7111.
[44]	江斌, 杨承伟, 何华锋. 毛冬青汤对膝关节镜术后患者血清ESR、CRP水平的影响[J]. 内蒙古中医药, 2021, 40(1):14-15.
[45]	GARCIA-LAZARO ROCIO S, LAMDAN HUMBERTO, CALIGIURI LORENA G, et al. In vitro and in vivo antitumor activity of Yerba Mate extract in colon cancer models.[J]. Journal of food science, 2020, 85(7):2186-2197. doi: 10.1111/jfds.v85.7 URL
[46]	CITTADINI MARIA C, REPOSSI GASTON, ALBRECHT CLAUDIA, et al. Effects of bioavailable phenolic compounds from Ilex paraguariensis on the brain of mice with lung adenocarcinoma.[J]. Phytotherapy research: PTR, 2019, 33(4):1142-1149. doi: 10.1002/ptr.v33.4 URL
[47]	CHEN JING, DU Y S, LONG Y Y, et al. Polyphenols in Ilex latifolia Thunb. inhibit human lung cancer cell line A549 by regulation of the PI3K-Akt signaling pathway.[J]. BMC Complementary medicine and therapies, 2022, 22(1):85. doi: 10.1186/s12906-022-03568-3 pmid: 35321703
[48]	陈颖. 大叶冬青叶三萜类成分抗乳腺癌作用及质量标准研究[D]. 芜湖: 皖南医学院, 2019.
[49]	臧莉, 王宏婷, 王存琴. 大叶冬青叶中27-CAUA对人乳腺癌MDA-MB-468细胞增殖的影响[J]. 皖南医学院学报, 2021, 40(6):519-522.
[50]	臧莉. 大叶冬青叶中27-O-p-(E)-coumaroyl ursolic acid抑制乳腺癌细胞作用及其机制研究[D]. 芜湖: 皖南医学院, 2021.
[51]	杨彩梅. 铁冬青酸对人肺腺癌细胞增殖、迁移和侵袭能力的影响[D]. 合肥: 安徽医科大学, 2022.
[52]	WANG ZHONG-FENG, SUN WEN-YI, YU DE-HAI, et al. Rotundic acid enhances the impact of radiological toxicity on MCF-7 cells through the ATM/p53 pathway.[J]. International journal of oncology, 2018, 53(5):2269-2277.
[53]	GAURAB ROY, GUAN SU, LIU H X, et al. Rotundic acid induces dna damage and cell death in hepatocellular carcinoma through AKT/mTOR and MAPK pathways[J]. Frontiers in oncology, 2019, 9:545. doi: 10.3389/fonc.2019.00545 pmid: 31293977
[54]	CHEN GANG, ZHANG LIN, CHEN L Y, et al. Rotundic acid regulates the effects of Let-7f-5p on Caco2 cell proliferation[J]. Anti-cancer agents in medicinal chemistry, 2021, 21(7):902-909. doi: 10.2174/1871520620999200730165829 URL
[55]	LI QIU, HAO Z H, HONG Y T, et al. Reprogramming tumor associated macrophage phenotype by a Polysaccharide from Ilex asprella for Sarcoma immunotherapy[J]. International journal of molecular sciences, 2018, 19(12):3816. doi: 10.3390/ijms19123816 URL
[56]	陈颖. 毛冬青甲素对白血病K562细胞自噬性凋亡LC3通路调控影响的研究[D]. 长沙: 湖南中医药大学, 2019.
[57]	YU D H, ZHU Z Y, WANG MEI, et al. Triterpenoid saponins from Ilex cornuta protect H9c2 cardiomyocytes against H₂O₂-induced apoptosis by modulating Ezh2 phosphorylation[J]. Journal of ethnopharmacology, 2021, 269:113691. doi: 10.1016/j.jep.2020.113691 URL
[58]	冯思颖, 黄敏玲, 吴威妮, 等. 基于网络药理学探讨黄芩、毛冬青药治疗冠心病的作用机制[J]. 现代中西医结合杂志, 2020, 29(28):3133-3138,3184.
[59]	白荣钰, 易欢, 邱静文, 等. 毛冬青三萜皂苷对动脉粥样硬化大鼠粪便和尿液代谢组学的影响[J]. 南京中医药大学学报, 2022, 38(5):424-431.
[60]	易欢. 毛冬青三萜皂苷干预动脉粥样硬化大鼠肠道菌群和代谢组学研究[D]. 广州: 广州中医药大学, 2019.
[61]	白荣钰, 易欢, 陈丰连, 等. 毛冬青三萜皂苷对动脉粥样硬化大鼠肠道菌群的影响[J]. 中草药, 2021, 52(20):6245-6253.
[62]	商雪莹. 毛冬青三萜皂苷在血管内皮细胞的转运及基于自噬的药效机制研究[D]. 广州: 广州中医药大学, 2019.
[63]	李庆双, 郑关毅, 张碧琴, 等. 毛冬青甲素对大鼠骨髓间充质干细胞增殖及迁移的影响[J]. 中国药理学通报, 2018, 34(3):358-364.
[64]	曹迪. 毛冬青组分体内过程及其干预血瘀证大鼠的代谢组学研究[D]. 广州: 广州中医药大学, 2019.
[65]	胡科, 张保朝, 贾东佩, 等. 毛冬青皂酮胶囊对急性脑梗死模型大鼠神经保护作用[J]. 中医学报, 2020, 35(9):1950-1956.
[66]	康乐, 苗明三, 白明, 等. 毛冬青皂酮胶囊对大鼠短暂脑缺血发作模型的保护作用研究[J]. 中药药理与临床, 2018, 34(3):165-169.
[67]	杨爱萍, 张启春, 宋祎, 等. 具柄冬青苷对大鼠急性心肌缺血/再灌注损伤的保护作用研究[J]. 中国药理学通报, 2021, 37(4):484-489.
[68]	邹清容, 禤丽萍, 吕一燕, 等. 毛冬青对妇产科手术感染伤口疼痛的影响[J]. 黑龙江医学, 2018, 42(4):362-363.
[69]	禤丽萍, 吕一燕, 邹清容, 等. 毛冬青外治妇产科腹部术后切口感染40例[J]. 中国民族民间医药, 2018, 27(1):126-127,132.
[70]	吕一燕, 陈端, 黄涛, 等. 毛冬青液在妇产科术后腹部切口感染的应用效果[J]. 广西医学, 2018, 40(6):689-691.
[71]	胡佩欣, 柴计委, 望华南, 等. 冬青油腹部按摩对内镜下大肠息肉摘除术围术期病人负性情绪的影响[J]. 全科护理, 2022, 20(31):4398-4400.
[72]	姜丽. 冬青油腹部按摩治疗小儿食滞腹痛疗效观察[J]. 临床医药文献电子杂志, 2019, 6(36):36.
[73]	梁华丽. 毛冬青叶浓缩液联合聚维酮碘治疗Ⅰ、Ⅱ度烧伤的疗效观察[J]. 中国现代药物应用, 2018, 12(21):209-211.
[74]	XIE M H, CHEN G J, WAN PENG, et al. Effects of dicaffeoylquinic acids from Ilex kudingcha on Lipid metabolism and intestinal microbiota in high-fat-diet fed mice[J]. Journal of agricultural and food chemistry, 2018, 67(1):171-183. doi: 10.1021/acs.jafc.8b05444 URL
[75]	PACHURA NATALIA, KUPAZYNSKI ROBERT, LEWANDO WSKA KAMILA, et al. Biochemical and molecular investigation of the effect of Saponins and Terpenoids derived from leaves of Ilex aquifolium on lipid metabolism of obese zucker rats[J]. Molecules, 2022, 27(11):3376. doi: 10.3390/molecules27113376 URL
[76]	刘伟, 向星亮, 黄荣增, 等. 苦丁茶对高胆固醇脂血症小鼠血清多不饱和溶血磷脂酰胆碱的改善作用[J]. 中国医院药学杂志, 2018, 38(1):54-58.
[77]	SHI Z Y, AN L J, ZHANG S J, et al. A heteropolysaccharide purified from leaves of Ilex latifolia displaying immunomodulatory activity in vitro and in vivo[J]. Carbohydrate polymers, 2020, 245:116469. doi: 10.1016/j.carbpol.2020.116469 URL
[78]	舒翔, 程明, 王辉, 等. 苦丁茶冬青多糖对小鼠脾脏淋巴细胞的免疫调节和抗氧化作用[J]. 食品工业科技, 2022, 43(17):387-393.
[79]	MU J F, YANG F P, TAN FANG, et al. Determination of polyphenols in ilex kudingcha and insect tea (leaves altered by animals) by ultra-high-performance liquid chromatography-triple quadrupole mass Spectrometry (UHPLC-QqQ-MS) and comparison of their anti-aging effects[J]. Frontiers in pharmacology, 2021, 11:600219. doi: 10.3389/fphar.2020.600219 URL
[80]	PALUCH EMIL, OKINCZYC PIOTR, ZWYRZYKOWSKWOD ZINSKA ANNA, et al. Composition and antimicrobial activity of Ilex leaves water extracts[J]. Molecules, 2021, 26(24):7442. doi: 10.3390/molecules26247442 URL
[81]	张馨月, 李婷, 何改改, 等. 广西毛冬青根对放射脑损伤小鼠认知功能障碍的改善作用及其机制研究[J]. 广西医科大学学报, 2022, 39(9):1363-1370.
[82]	KIM CHANGKWON, AHN JEONGJUN, YU JAYEON, et al. Analysis of antioxidant constituents from Ilex rotunda and evaluation of their blood-brain barrier permeability[J]. Antioxidants, 2022, 11(10):1989. doi: 10.3390/antiox11101989 URL

中文名	别名	拉丁学名	主要分布地区	食用方式	药用价值
大叶冬青	宽叶冬青	Ilex latifolia	浙江、广西	叶入药、泡饮、水煎	疏风清热；明目生津
铁冬青	救必应	Ilex rotunda	广东、广西	茎皮、叶、根入药	清热解毒；利湿止痛
毛冬青	茶叶冬青	Ilex pubescens	广东、福建	根入药	清热解毒；止痛消炎
苦丁茶冬青		Ilex Kudingcha	广西	叶入药、泡饮、水煎	清热解毒；祛暑
枸骨	老虎刺	Ilex cornuta	江苏、安徽	叶入药、泡饮	清热养阴；补肝益肾
冬青	四季青	Ilex chinensis	广东、福建	叶、根和树皮入药	清热解毒；消肿祛瘀
秤星树	梅叶冬青	Ilex asprella	广东、广西	根、叶入药	清热解毒；消肿散瘀
广东冬青		Ilex kwangtungensis	浙江、江西	根入药	消肿止痛；清热解毒
小果冬青	细果冬青	Ilex micrococca	安徽、福建	树皮入药	止痛
榕叶冬青	仿腊树	Ilex ficoidea	安徽、浙江	根入药	消肿止痛；治疗跌打损伤
尾叶冬青	江南冬青	Ilex wilsonii	广东、云南	根、叶入药	清热解毒；消肿止痛
黄毛冬青		Ilex dasyphylla	江西、广西	根入药	清热解毒
大果冬青	见水蓝	Ilex macrocarpa	陕西、四川	根入药	清热解毒；润肺止咳
香冬青		Ilex suaveolens	浙江、云南	根入药	清热解毒；活血止血
具柄冬青	落霜红	Ilex pedunculosa	安徽、湖北	叶入药	祛风除湿；散瘀止血
绿冬青	亮叶冬青	Ilex viridis	安徽、福建	根、叶入药	溶血解毒；祛腐生新
三花冬青	小冬青	Ilex triflora	安徽、浙江	根入药	疮疡肿毒；跌打损伤
海南冬青	山绿茶	Ilex hainanensis	海南、贵州	叶入药	清热平肝；利咽解毒
珊瑚冬青	毛枝珊瑚冬青	Ilex corallina	甘肃、湖北	叶、根、皮入药	抑菌、清热解毒
巴拉圭冬青		Ilex paraguariensis	阿根廷、巴西	叶入药、泡饮	解乏；利尿；抗炎
欧洲冬青		Ilex europaeus	欧洲、非洲	叶入药	利尿；缓解发烧症状

中文名	别名	拉丁学名	主要分布地区	食用方式	药用价值
大叶冬青	宽叶冬青	Ilex latifolia	浙江、广西	叶入药、泡饮、水煎	疏风清热；明目生津
铁冬青	救必应	Ilex rotunda	广东、广西	茎皮、叶、根入药	清热解毒；利湿止痛
毛冬青	茶叶冬青	Ilex pubescens	广东、福建	根入药	清热解毒；止痛消炎
苦丁茶冬青		Ilex Kudingcha	广西	叶入药、泡饮、水煎	清热解毒；祛暑
枸骨	老虎刺	Ilex cornuta	江苏、安徽	叶入药、泡饮	清热养阴；补肝益肾
冬青	四季青	Ilex chinensis	广东、福建	叶、根和树皮入药	清热解毒；消肿祛瘀
秤星树	梅叶冬青	Ilex asprella	广东、广西	根、叶入药	清热解毒；消肿散瘀
广东冬青		Ilex kwangtungensis	浙江、江西	根入药	消肿止痛；清热解毒
小果冬青	细果冬青	Ilex micrococca	安徽、福建	树皮入药	止痛
榕叶冬青	仿腊树	Ilex ficoidea	安徽、浙江	根入药	消肿止痛；治疗跌打损伤
尾叶冬青	江南冬青	Ilex wilsonii	广东、云南	根、叶入药	清热解毒；消肿止痛
黄毛冬青		Ilex dasyphylla	江西、广西	根入药	清热解毒
大果冬青	见水蓝	Ilex macrocarpa	陕西、四川	根入药	清热解毒；润肺止咳
香冬青		Ilex suaveolens	浙江、云南	根入药	清热解毒；活血止血
具柄冬青	落霜红	Ilex pedunculosa	安徽、湖北	叶入药	祛风除湿；散瘀止血
绿冬青	亮叶冬青	Ilex viridis	安徽、福建	根、叶入药	溶血解毒；祛腐生新
三花冬青	小冬青	Ilex triflora	安徽、浙江	根入药	疮疡肿毒；跌打损伤
海南冬青	山绿茶	Ilex hainanensis	海南、贵州	叶入药	清热平肝；利咽解毒
珊瑚冬青	毛枝珊瑚冬青	Ilex corallina	甘肃、湖北	叶、根、皮入药	抑菌、清热解毒
巴拉圭冬青		Ilex paraguariensis	阿根廷、巴西	叶入药、泡饮	解乏；利尿；抗炎
欧洲冬青		Ilex europaeus	欧洲、非洲	叶入药	利尿；缓解发烧症状

化合物	来源	药理活性	文献
(2S)-7-methoxy-3′,4′-dihydroxy-5,8-quinoflavan	华中枸骨(Ilex centrochinensis)	抗炎活性	[23]
Pubescenoside N；Pubescenoside O	毛冬青(Ilex pubescens)	抗血小板聚集	[24]
rotundarpenes A-B	铁冬青(Ilex rotunda)	抗炎活性	[30]
matesaponin 1；matesaponin 2	巴拉圭冬青(Ilex paraguariensis)	抗肥胖活性	[31]
Asprellcosides B	秤星树(Ilex asprella)	抗病毒活性	[32]
LCFP-3	枸骨(Ilex cornuta)	抗炎活性	[33]
Rotundic acid	铁冬青(Ilex rotunda)	抗炎活性	[34]
Ilexhainanoside D	海南冬青(Ilex hainanensis)	抗炎活性；改善肠道屏障	[35]
dicaffeoylquinic acids	苦丁茶(Ilex Kudingcha)	抗炎活性；	[36⇓-38]
27-O-p-(E)-coumaroyl ursolic acid	大叶冬青(Ilex latifolia)	抗癌作用	[50]
IAPS-2	秤星树(Ilex asprella)	抗肿瘤活性	[55]
ILP50-2	大叶冬青(Ilex latifolia)	免疫调节活性	[77]
4,5-dicaffeoylquinic acid	铁冬青(Ilex rotunda)	治疗中枢神经系统	[82]

化合物	来源	药理活性	文献
(2S)-7-methoxy-3′,4′-dihydroxy-5,8-quinoflavan	华中枸骨(Ilex centrochinensis)	抗炎活性	[23]
Pubescenoside N；Pubescenoside O	毛冬青(Ilex pubescens)	抗血小板聚集	[24]
rotundarpenes A-B	铁冬青(Ilex rotunda)	抗炎活性	[30]
matesaponin 1；matesaponin 2	巴拉圭冬青(Ilex paraguariensis)	抗肥胖活性	[31]
Asprellcosides B	秤星树(Ilex asprella)	抗病毒活性	[32]
LCFP-3	枸骨(Ilex cornuta)	抗炎活性	[33]
Rotundic acid	铁冬青(Ilex rotunda)	抗炎活性	[34]
Ilexhainanoside D	海南冬青(Ilex hainanensis)	抗炎活性；改善肠道屏障	[35]
dicaffeoylquinic acids	苦丁茶(Ilex Kudingcha)	抗炎活性；	[36⇓-38]
27-O-p-(E)-coumaroyl ursolic acid	大叶冬青(Ilex latifolia)	抗癌作用	[50]
IAPS-2	秤星树(Ilex asprella)	抗肿瘤活性	[55]
ILP50-2	大叶冬青(Ilex latifolia)	免疫调节活性	[77]
4,5-dicaffeoylquinic acid	铁冬青(Ilex rotunda)	治疗中枢神经系统	[82]