Abstract: [Objective] Understanding the Epidemiology regulation of the Classical swine fever in Henan, studying infection circumstance of Classical swine fever virus, checking thoroughly immunization about Vaccine of Classical Swine fever virus. [Methods] 301 specimen are detected by ELISA kit for CSFV antigen, at the same time, we smeared, dyed and looked at bacterium and found out mixed infection about bacterium and CSFV. We took integrate control measures to CSFV antigen positive hogpens and tracked the administration；and investigated mixed infection with Porcine reproductive and respiratory syndrome （PRRS）and Porcine circovirus Ⅱ（PCV2）in the hogpens. [Results] CSF is widely in Henan, the CSFV average detectable rate is 26.25%. Bacterium infection ratio is twenty-five point three one in all the CSFV antigen positive hogpens. The comprehensive measures is effective to treat CSF. [Conclusion] The comprehensive measures is very important for purifying CSFV, but bacteria, PRRSV and PCV-Ⅱmixing infection with CSFV in pigs is main reason that purifying CSFV is different.