Abstract: Through the test effect of the biocide ,the pesticide stemming from botany,the chemical pesticide most in use which specialize in eliminating “Locusta migratoria manilensis Meyen” shrouding the fields in Yellow-River beach area Zhongmou County Henan Province between 2005 and 2006, the result clearly indicates: Using 30% of Metarhizium Anisipliae LUV to eliminate locusts with capacity of 167~250ml/hm2, 14 days later, average elimination rate is about 90%.Using0.3% of Matrine with capacity of 900ml/hm2 and 1% of Celangulins with capacity of 300 ml/hm2, average elimination rate of the two eliminating locusts is higher than 90% respectively. Compared with middle-poison Fipronil and low-poison Malathin , the result of effects is very close to the former ,and better than latter. Since Metarhizium, Matrine, Celangulins all belong to low-poison biocide and low-poison pesticide stemming from botany, we can use them as a substitute for organic phosphorus pesticide and cycloprothrin pesticide.