Abstract: Effect of different kinds of organic manure including fully-fermented pig manure, oil cake and fully-fermented crop straw and different application time on growth of flue-cured tobacco was studied in field experiment. Results showed that all treatment promoted the growth of flue-cured tobacco, as compared with the control of just manuring chemical fertilizer. Leaf area of upper leaf were increased, if employed decomposed hog manure during proceeding crop, but rates of first and secondary class and equal price were decreased. And rates of first and secondary class and equal price were increased when employed stalks left, no better production value. Straw left employed during proceeding crop can lead to higher nitrate nitrogen content during flue-cured tobacco. The production value of tobacco leaf when oil marc was employed in proceeding crop was better than that employed in flue-cured tobacco season. Chemical fertilizer and decomposed hog manure were mixed to employ in flue-cured tobacco season, which could enhance the production value of tobacco leaf.