Abstract: Etiological agents of twenty swine cases infected by PRRSV doubtfully, which characteristic are high fever, are detected by PCR, bacterial culture, microscopic examination on blood smear in the paper. Then the means of integrated control on the disease are produced according to origins of the disease. The experiments shows masculine rate of PRRSV, PCV-2, PRV, CSFV is 100%, 40%, 40%, 10% respectively and that of Eperythrozoonsis is 90%. SI and APP are negative. A small quantity cases are also infected by few bacteria. The result indicates that high pathogenicity PRRS are taken place in our city. The sick swines are also secondary infected by other pathogens in different degree. The kinds of pathogens are 3 to 5 commonly. The diversification of pathogens leads to complication of pathogenetic condition, so that the degree of difficulty about diagnosis and cure rises. So the means of integrated control on the disease shall be adopted properly