Abstract: The quality character of specific flue-cured tobacco leaves was better aromatic particularity and higher aromatic quantity. The quality formed mechanism of specific flue-tobacco leaves remained poorly understood. In the present study, we reviewed the articles about defense response of tobacco and other plants to oxidative stress induced by abiotic stresses. Proposed that precursors of tobacco leaves aromatic substances, such as 円-carotene, phenolic compounds, reducing sugar, and amino acid, had reductive property and probably were the production of defense response to oxidative stress induced by abiotic stresses. Precursors of flue-tobacco leaves aromatic substances probably were main non-enzyme antioxidants. The quality of specific flue-tobacco leaves may be formed by defending oxidative stress. If studying it thoroughly the quality formed mechanism of specific flue-tobacco leaves would be revealed.