Abstract:

Abstract: To study the protective effects of compound honeysuckle and Herba Artemisiae Scoparia injection on heart and lung’s tissue structure injury induced by the endotoxin. The weight of healthy rabbits was 2.5±0.25kg, they were randomly divided into 4 groups, the model group, the honeysuckle compound group and the Herba Artemisiae Scoparia group were injected the endotoxin saline with intravenous, the dose was 100μg/ kg, after 24h, the Compound Honeysuckle and Herba Artemisiae Scoparia groups were injected the Chinese medicine with intravenous, the dose was 10ml/kg. The model group was injected same volume saline intravenously. The negative control group was injected same volume saline intravenously with the endotoxin and Chinese medicine injection group, after 24 hours, jugular vein bleeding to death, take heart, lung tissue, Bouin liquid fixed 24h, made paraffin sections, stained of HE, microscope and photography. The results showed that the rabbit of model group myocardial fibers were swelling, parts of fracture, interstitial congestion, around vascular edema, the cell of myocardial had vacuolar degeneration, the dispersivity edema of lung, the small vascular hyperemia in interstitial of lung, there were the phenomenon of neutrophils accumulation in the lumen, the micro thrombus formed, around small vascular congestion; the massive inflammatory infiltration, the structure of alveolar was damaged. The rabbit of Compound Honeysuckle group myocardial fibers arranged tidiness, there were a little congestion around myocardial fibers; the most parts of alveolar septa normal, the small parts of swelling, thickening. Herba Artemisiae Scoparia group heart, lung tissue structure compared with the model group has basically not changed.