Abstract:

Porcine reproductive and respiratory syndrome (PRRS), caused by porcine reproductive and respiratory syndrome virus (PRRSV), is considered one of the most important contagious diseases in swine industry today and responsible for significant economic losses worldwide. Reverse genetics manipulation has been used extensively in variety of fields of life science for several decades, which supports us a powerful method to explore organisms. This paper mainly summarized the application and perspective of reverse genetics manipulation in the research of PRRS, including virus rescue, vaccines development, molecular etiology diagnosis and so on.