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中国农学通报

中国农学通报 ›› 2012, Vol. 28 ›› Issue (11): 89-92.doi: 10.11924/j.issn.1000-6850.2011-2690

所属专题： 畜牧兽医

• 畜牧 动物医学 蚕 蜂 • 上一篇    下一篇

γ-氨基丁酸对热应激大鼠新生子代的发育及抗氧化力的影响

范志勇1,2,3,邓近平1,3,杨玲媛1,3,朱立涛1,3,杨丹丹1,3   

  • 收稿日期:2011-09-18 修回日期:2011-11-04 出版日期:2012-04-15 发布日期:2012-04-15

Effects of γ-aminobutyric Acid on Development and Antioxidant Ability of Neonates of Heat-Stressed Rats

  • Received:2011-09-18 Revised:2011-11-04 Online:2012-04-15 Published:2012-04-15

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摘要：

为研究日粮中添加γ-氨基丁酸对热应激大鼠子代发育和抗氧化功能的影响，选用90日龄的Sprague-Dawley大鼠52只(雌性大鼠39只，雄性13只)进行试验，交配后27只受孕雌鼠随机分为三组，正常对照组，热应激组和GABA热应激组，仔鼠出生后1天，测定发育指标和肝脏抗氧化指标。结果显示，与正常对照组相比，热应激组新生雌鼠和雄鼠的尾长均显著降低(P＜0.01)；新生大鼠的肝脏谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)活性有所降低，丙二醛(MDA)含量有所升高，但差异均不显著。与热应激组相比，GABA热应激组新生雌鼠(P＜0.01)和雄鼠(P＜0.05)的尾长均显著提高；新生大鼠的肝脏MDA含量有所降低，GSH-Px、SOD活性有所升高，但差异均不显著。结果提示GABA一定程度上可改善孕期热应激条件下新生大鼠的抗应激能力。

关键词: FA旱地龙, FA旱地龙, 盐渍化棉田, 施用量, 土壤改良

Abstract:

The effects of dietary γ-aminobutyric acid (GABA) on development and antioxidant ability of neonates of heat-stressed rats were investigated. Fifty-two rats aged 90 days, thirteen-nine females and thirteen males, were the experimental subjects. Twenty-seven pregnant rats were randomly divided into three groups after mating: the control group, the heat-stressed group and the GABA heat-stressed group. The development indices and hepatic antioxidant indices of 1 d neonates were measured. The results showed that tail lengths of the female and male neonates from the heat-stressed group fed with basal diet were both decreased very significantly (P＜0.01) compared with that of the control group, while the hepatic malondialdehyde (MDA) contents increased slightly, activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) decreased slightly. Compared with the heat-stressed pregnant rats fed with basal diet, tail lengths of the female (P＜0.01)and male (P＜0.05) neonates from the GABA group, but MDA contents decreased slightly and activities of GSH-Px, SOD increased slightly. The results indicated that GABA could improve anti-heat-stress ability in neonatal rats under heat stress condition during pregnancy.