Abstract: In order to improve fruit quality, fruit yield and fruit tree of life, overcome side effects of chemical agents to fruit, fruit trees, the human body and the environment, using the beeswax, propolis extracts and Chinese herbal medicine extracts compound, the formation of deep coffee color paste preparation has better effects of prevention and cure on fungal diseases of fruit trees. In the laboratory, with extracts of propolis and Chinese herbal medicine for antibacterial test, results showed that the diluted concentration of 50% propolis extracts on Penicillium cyclopium and Aspergillus niger had significant inhibiting effect; the diluted concentration of 20% Chinese herbal medicine extracts on these 2 species of fungi had extremely significant inhibiting effect. With 2 factors and 3 levels, orthogonal test (no interaction) and inhibiting fungi experiment were carried out. We found that the combination of A1B3 was the optimal combination, the antibacterial rate more than 90% to 2 species of fungi. In the orchard, smearing of propolis beeswax compound preparation on pruning branches and suffer from rot fruit trees, can play a good effect of protection and control.