Abstract: Spatial evolution of China’s regional economy has a close correlation with sustainable economic and social development, so it is of important implications to explore land use and cover change for the future. We selected the area of Hubei Han River typical ecological and economic zone, which was in the central region of China’s industrial development and ecological protection, to analyze three basic periods remote sensing image supervised classification in the year of 2000, 2007, and 2013 with RS technology. We also used the index of land dynamic, the integrated land use degree index, the relative rate of change of a single land-use and other mathematical models to quantitatively analyze the land use pattern and temporal evolution of features in Han River ecological and economic zone for about 13 years. It showed that: land use structure along Han River in Hubei was ecologically and economically unstable from 2000-2013. Han River ecological economic zone arable land had decreased 10256.4756 km² in recent 13 years. From land-use transfer matrix analysis, arable land mainly turned to woodland. And from remote sensing image comparison, arable land around the city was eroded by urban construction, and the water region was changed in the minimum. From the single dynamic analysis of land use, land for construction was changed dramatically from 2007 to 2013, and the dynamic level was 4.826%. From the aspects of regional variations, land use was significantly changed around prefecture cities (provincial cities). The change rate of the water region was larger in Hanyang and Qianjiang, but the change rate in Shennongjia Scenic was the least.