Abstract: In order to quantitatively analysis the laws of flowering and seed-setting for winter wheat, [Method]the field experiment of varieties and nitrogen was carried out in 2013-2014 growth reason for winter wheat. “Jimai 22”, “Tainong 18”, and “Luyuan 502” were used as the experiment material in the study. A model of estimating seed-setting rate for winter wheat was built by analyzing the relationship among the fertile florets, flowering number and seed-set at pre-overwintering, and the relationship between the average single daily flower number and the single daily seed-setting rate for single spike and the growth degree days after anthesis. [Result]The model was validated by using independent experiment dataset. The result showed that root mean squared error (RMSE), mean absolute error (da) and the determined coefficient (R2) between simulated and measured values of seed-setting rate were 1.092% (n=9), 0.934%, and 0.617, respectively; the correlation between observation and simulation in the geometrical parameter were significant at P<0.05, and the simulated values agreed well with the measured ones. [Conclusion]It indicated that the winter wheat seed setting rate could be well simulated by these models.