Abstract: Abstract:[Objective] [Method]In order to provide a more economical and efficient application technology of water and nitrogen for winter wheat, the effects of nitrogen fertilizers and irrigation time on the agronomic characters, economic coefficient, yield, and yield components were studied. [Method] Through the two factor split plot experiment, the Main plot set 3 levels, which are pre-sowing water, pre-sowing water jointing water, pre-sowing water jointing water grain filling water. Sub plot set 5 levels, which are 0 kg/hm2,120 kg/hm2,240 kg/hm2,300 kg/hm2,360 kg/hm2, three repetitions were adopted in the test, and the analysis method variance analysis, variance analysis and gray correlation were used in the test. [Result]Irrigation times and nitrogen fertilizer could significantly improve the agronomic traits, economic coefficient and yield of wheat during grain filling stage. The nitrogen fertilizer levels had significant effect on leaf area index, grain number per spike and yield, the irrigation times had significant effect on dry matter accumulation, leaf area coefficient, 1000 grain weight and spike number, and the nitrogen requirement of leaf area coefficient, grain number and yield was higher than the number of per plant, dry matter accumulation, economic coefficient, and the number of spike per plant; The jointing stage is the key period of winter wheat responses to water and nitrogen coordination, the yield will greatly increased, if there have adequate water and nitrogen. And the grain filling water will increase the efficiency of nitrogen utilization, reducing nitrogen application rate, yield was significantly improved. [Conclusion]When irrigation pre-sowing water jointing water grain filling water, and the nitrogen fertilizer level was 277.14 kg/hm2, the water and fertilizer can get efficient coordination, the yield of ‘Yujiao 5’will reach 8305.86 kg/hm2. Owing to insufficient rainfall at the late stage of winter wheat in eastern of Henan, the irrigation is the key measure to increase the yield of wheat, If the soil moisture is adequate, the nitrogen use efficiency will be increased, this can save the production cost of winter wheat, and can reduce or avoid the environmental pollution caused by excessive nitrogen application.