Abstract: Soil pollution has become an important problem affecting crop production and harming human health, it should be studied and solved urgently. The objectives are to provide theoretical support for the reduction of Cd, As, Pb, Cu, Zn bioavailability, develop techniques of heavy metal abatement in polluted soils in wheat production, and lay a foundation for field heavy metal pollution monitoring and comprehensive management. The single element pollution was used in this study. The effects of Cd, As, Pb, Cu and Zn stress on the growth and physiological indexes of wheat were studied by indoor hydroponic experiment and field trial. The results showed that low concentration of heavy metals promoted the germination of wheat seeds to a certain extent, while the high concentration of heavy metals inhibited the seed germination. In different treatments, the total aboveground dry matter content of wheat showed a“slow-fast-slow”growth trend. The plant height, spikelet number, sterile spikelet number and ear number decreased, the thousand seed weight increased, and the economic coefficient decreased, which resulted in the reduction of yield ultimately.