Abstract: To explore high-yield cultivation mode of the big-spike wheat varieties and give full play to their yield-increasing potential, under field condition, taking‘Shangmai 156’as the experimental material, we used randomized block experiment design and studied the effects of sowing date, sowing quantity, line spacing and repression on tillering and spike formation and yield. The results showed that the yield reached the maximum when the sowing date was October 11th, it was significantly different from that of other treatments except sowing date October 16th. The yield was the highest when the basic seedlings was 3.0 million/hm2, and it was significantly different from that of other treatments except 3.75 million/hm2. The yield and the number of spike per unit area were the highest when the line spacing was 16.7 cm, followed by those of 20 cm, and the two treatments had significant difference with the other treatments. Repression at returning green stage increased the number of tiller and spike per plant, too much repression caused the increase of ineffective tiller, which could not promote the yield obviously. In production, sowing date from October 11th to October 16th, the basic seedling of 3 million/hm2 to 3.75 million/hm2 and the row spacing of 16.7cm to 20 cm is suitable for‘Shangmai 156’. When the group is too large, moderate repression could be done to reduce the plant height and increase the resistance of wheat.