Abstract: Acanthopanax senticosus has been gathered intensively due to its high medicinal value, causing extreme damage to Acanthopanax senticosus resources. Exploring the suitable growth soil of Acanthopanax senticosus will provide a theoretical basis for its artificial domestication. In this paper, the soil which had been planted with Acanthopanax senticosus in Qitaihe City for many years, was taken as the research object. The chemical properties of soil profile of typical soil where Acanthopanax senticosus grew were determined by chemical analysis methods. The results showed that the particle composition of soil which was suitable for Acanthopanax senticosus to grow was mainly composed of more than 60% of sand, followed by more than 20% of powder, and the porosity was high. The surface layer was mostly granular structure, and the deep layer was mostly massive structure. The soil temperature was between 0℃ and 8℃ and the soil water content was between 40% and 60%. The organic matter content in the surface layer of the soil was relatively high, which was 46.51-58.83 g/kg, accounting for 50.0%-59.6% of the organic matter content in the whole soil profile. The total nitrogen content in the surface layer was relatively high, which was 2.18-2.51 g/kg, accounting for 35.1%-36.5% of the total nitrogen content in the whole profile. The characteristics of vertical profile was that the organic matter content showed a dramatic drop with the increase of soil depth, and the total nitrogen content also decreased with the increase of soil depth. However, the total phosphorus content in the surface layer of the soil was relatively low between 0.21 and 0.44 g/kg, and the total phosphorus content in the surface layer accounted for 42.0%-49.4% of the whole profile. The pH value of the soil was between 5.75 and 5.97, which was weakly acidic to neutral. The total phosphorus content and pH did not show obvious vertical variation. Acanthopanax senticosus is adapted to the growth of loose soil texture, mostly sandy loam soil, cold temperature condition, wet moisture condition, and fertile soil. The soil organic matter content and total nitrogen content of surface soil are high, and the soil is weakly acidic to neutral.