Abstract: Ecological security can be explained from broad-sense and narrow-sense. Since the wider area and regional discrepancy in influenced factors and eco-background, the regional environment hasn’t been studied systematily. The paper built the Stress-response-regulation model according to the interaction between human and environment, and analysis the safety degree of west part of Jilin province in 2000 using compound model and Grid method based on GIS and RS. The results show that most part of the study area belong to the security state while the risk and non security area distributed in the middle and west part of the study area, furthermore, the state of east is better than that of west. When talk about ten counties of the region, absolute security account for a very small quantity, and the county that has widest area of security is Qian’an while the smallest is Da’’an. Tao’nan is the county that the area of risk is biggest, 43.08 percent of whole county area and the that of Qian’an is smallest, accounting for 1.56 percent only. The area of non security of Tongyu, zhenglai and Da’an have exceeded 10 percent and been the urgently treatmented region. Coupling between ecological security and type of land use showed that the farm belt is relatively stable while pasturing area has been distroied furthest. Although the value of grass is more than that of farmland by the Constanz’s theory of ecological value, the cover degree of grass in study is lower and when there is disturbance, whole system lost balance.