Abstract:

In order to investigate antimicrobial effect to Streptococcus suis serotype Ⅱ on Chinese herbal preparation of Yinqiaotiangan in vivo. The prevention and treatment test was carried with Kunming mice about 18-22 g weight. In the prevention trial these mice were attacked by the Streptococcus suis serotype Ⅱ, at the same time, taken orally 0.5 g/mL, 1.0 g/mL and 2.0 g/mL Chinese herbal preparation of Yinqiaotiangan respectively. And then the incidence, mortality, and protective rate were detected after 7 days when the Chinese herbal preparation was continuous used 3 d, once a day. In the treatment test, the Streptococcus suis serotype Ⅱ disease model was established in Kunming mice. Then these mice were taken orally 0.5 g/mL, 1.0 g/mL and 2.0 g/mL Chinese herbal preparation of Yinqiaotiangan respectively. The cure rate, effective rate and incidence were detected after 7 days when the preparation of Yinqiaotiangan was continuous used 3 d, twice a day. The prevention trial results showed that the protective rate in experimental groups were significantly higher than those in control (P<0.01), the incidence and mortality were significantly lower than that of the control (P<0.01). The treatment test results showed that the incidence of the Chinese herbal preparation groups was significantly lower than that of control group (P<0.01), the cure rate of low dose group were higher than that of middle and high dose group (P<0.01), and the effective rate of low dose group was significantly higher than that of middle and high dose group (P<0.05). So the pathologic model of Streptococcus suis serotype Ⅱ could be effectively prevented and treated by oral the low dose Yinqiaotiangan preparation in Kunming mice.