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Chinese Agricultural Science Bulletin ›› 2013, Vol. 29 ›› Issue (18): 175-179.doi: 10.11924/j.issn.1000-6850.2012-1888

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Preparation and Release Kinetics of Multi-functional Mothproofing Sustained-release Tablets Based on Eupatorium Powders as a Carrier

  

  • Received:2012-05-18 Revised:2012-07-17 Online:2013-06-25 Published:2013-06-25

Abstract: In order to prepare the aromatic and mothproofing sustained-release tablets based on eupatorium powders, the absorbents and excipients appropriately incorporated into the tablets were selected by using compression formulation experiment and in vitro release experiment. The influence of the compositions of the tablets and formulation conditions on the release kinetics was investigated using in vitro dynamic release experiments. The efficacies of tablets were evaluated by test insects. The results showed that: Micro-silica powders appropriately incorporated into the tablets had good compressibility and controlled-release effect. The sustained-release tablets could be successfully prepared by using eupatorium powders as a carrier and the formulation pressure of 10 MPa. The obtained lavender flavor-containing eupatorium-based tablets had good appearance and the maximum amount of eupatorium powders could reach 76% (m/m) of the quality of the tablet, and the release of lavender flavor from the tablets sustained more than 3 months. The incorporation of a certain amount of lavender flavor into the tablets could not only mask the bad smell of eupatorium dry powders but also improve the mothproofing efficacy of the tablets. In this study, the aromatic and mothproofing sustained-release tablets can be successfully prepared. The obtained results can not only broadens the scope of the comprehensive utilization of eupatorium, but also provide a multi-functional mothproofing sustained-release tablets with aromatic flavor for the domestic mothproofing market.

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