Abstract: It was found that the anthocyanins resources were rich in grape, and it was suggested that Comprehensive use of solvent extraction method, ultrasonic assisted solvent extraction method, enzymatic purification method, HPLC-MS method and so on in the purification process through the systematic analysis of Extraction, purification qualitative, quantitative determination and antioxidant effects of grape anthocyanins. At present, the ultrasonic assisted solvent extraction method has the advantages of short time, low energy consumption and high extraction rate, and this extraction technology has a wide application prospect. HPLC-MS method is the most widely used method for qualitative identification of grape anthocyanins, and this method can accurately detect the species, content and proportion of the contains anthocyanins from grape. In the last part, It was found that grape anthocyanins had a strong inhibitory effect on oxidative modification, and could fundamentally remove DPPH, O_2-, OH, H₂O₂ or other free radicals base, and also have a better inhibitory effect on lipid peroxidation through the summary analysis of antioxidant effects of grape anthocyanins in vitro and in vivo experiments.. Some species of grape anthocyanins can effectively reduce the occurrence of atherosclerosis, cardiovascular and cerebrovascular diseases, liver damage, acute lung injury and other diseases.