Abstract: The essential of land use and regional harmony development is to analyze and forecast whether or not land use is in favor of optimizing ecological patterns, obligated by the development trends of existing and future population, country economy and town economy. Using land use sift and its refresh data and interrelated social-economic datum of Qingzhen city, the frames of land use and regional harmony development in Qingzhen city are discussed in this paper with GIS, statistics method and experience evaluation. The results show that: (1) the land use dynamic behave as 6 types in Qingzhen city, but the land use are dominated by agricultural landscapes as a whole, the outskirts of a city mixed landscapes have not been formed. The leading factors which drive these land use dynamic changes are population increase, the expediting of city progress, the evolving of economic structure and the comparing benefit differentia of different land use. (2) For past 5 years, the absolute and relative difference of regional economy develop increased, but the amplitudes reduced in all villages and towns, namely, the regional economy development has a polarization trend in Qingzhen city. Several developed regions, such as Hongfenghu, Zhanjie, Weicheng and Xindian towns, have a more and more influences on the whole city. The gap between the most developed and most laggard regions increase continuously. (3) The frames of land use and regional harmony development will satisfy the need of local people inhabitants to food, and harmonize contradictions among provision safety, ecological safety and economy at one time. (4) The sustainable development must harmonize the relation of land use and regional development adequately in karst areas.