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Chinese Agricultural Science Bulletin ›› 2023, Vol. 39 ›› Issue (15): 132-138.doi: 10.11924/j.issn.1000-6850.casb2022-0365

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Improving the Production of 2,3-Butanediol by Saccharomyces cerevisiae Using the Theory of Synthetic Ecology: A Review

CAO Xinbo1(), YAN Tingwei1, ZHANG Wen1, REN Yanxin1, PEI Fangyi1, KANG Jie1, GE Jingping1,2()   

  1. 1 Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education & Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region & Key Laboratory of Microbiology, College of Heilongjiang Province & School of Life Sciences, Heilongjiang University, Harbin 150080
    2 Hebei University of Environmental Engineering, Hebei Key Laboratory of Agroecological Safety, Qinhuangdao, Hebei 066102
  • Received:2022-05-08 Revised:2022-08-15 Online:2023-05-25 Published:2023-05-22

Abstract:

2,3-Butanediol (2,3-BD) is widely used in many fields such as chemical industry, medicine and aerospace, and it is called an important platform compound. In order to solve the problem of huge demand for 2,3-BD and shortage of oil, this paper discusses the top-down and bottom-up construction of engineering microbial populations based on the analysis of the advantages of Saccharomyces cerevisiae in producing 2,3-BD, thus providing strategies to produce 2,3-BD by co-culture of Saccharomyces cerevisiae and companion strains. At the same time, from the perspective of synthetic ecology, this paper also summarizes its application in restoration ecology, medical treatment and production practice, and proposes the feasibility of using synthetic ecology theory to promote the production of 2,3-BD by Saccharomyces cerevisiae.

Key words: synthetic ecology, Saccharomyces cerevisiae, 2,3-butanediol, co-culture, engineering microbial communities