Abstract: Aqueous solution of 0.3% total alkaloids of Sophora alopecuroides was used to control Aphis sp. in Field of three areas. The results showed that the control effect of the solution diluting 800 times was better than the one diluting 1000 times. The effect was up to 90% in 7 days after the application in all three areas, and the effective duration delayed for 15 days. It was safe to wolfberry and could increase the yield of wolfberry compared with CK. It could be recognized the ideal bio-rational pesticide against the Aphis sp..