Abstract: Field trials and demonstrations were conducted to study the effects of 3 slow-release fertilizers (SRF), coated with natural vegetal materials, and 2 controlled-release fertilizers (CRF), coated with polymer materials, on yield and quality of wax gourd. Results of 2 years illustrated that yield-increasing effect of the SRF1 was significantly superior to other treatments, averaging in 15.6% higher yield over the treatment of normal splitting fertilization (NSF) under the same NPK rates. In addition, the SRF1 trended to improve quality of wax gourd through relatively increasing dry matter rate and concentrations of vitamin C and soluble sugar. In comparison to farmers’ NSF, the SRF1 resulted in significantly hiher yields in 2 of 3 demonstrations, with yield increase by 7.61% in average, meanwhile, reduced NPK application rates respectively by 6.73%, 71.1%, 46.0%, and fertilization cost by 40.0%.