Abstract: In order to promote the accurate management and fertilization of tobacco soil, spatial analysis on tobacco soil pH and middle-element was made by GIS and geostatistics in the tobacco region of Changtu, Liaoning province. The results showed that, the semivariograms for soil pH, available Ca, Mg and S contents were well fitted by exponential, spherical, gaussian and gaussian models, respectively. The four variables all had the moderate spatial correlation, indicating them co-affected by structural factors and random factors such as fertilization and field managements. The spatial distribution pattern of tobacco soil pH and available middle-elements in the tobacco region of Changtu was intuitively characterized by Kriging interpolation, which provided scientific basis for tobacco field management by regions.