Abstract: 【OBJECTIVE】to detect and analyze the group heredity of eight reproduction genes in F1 generation of wild boar and Large White pig, hope the result could be useful for crossbreed and marker assisted selection (MAS). 【METHOD】The genotypic frequencies and allele frequencies of eight genes related to reproduction, i.e. ESR, FSHβ, GPX5, FUT1, PRLR, NCOA1, OPN and RBP4 were tested in the 248 F1 generation hybrid pig (Large White ♀×wild boar♂) by PCR-RFLP. 【RESULTS】In F1 crossbred, ESR, FSHβ and PRLR predominance allele frequency had decrease trend, except FUT1 and GPX5, but NCOA1 and OPN’s were all higher than had been detected in crossbreds, only RBP4 was existed in Hardy-Weinberg equilibrium state. 【CONCLUSION】In breeding work of wild boar and domestic pig, it should select female parent group which contained highly predominance allele frequency of ESR、FSHβ and PRLR genes.