Abstract: In order to discuss the transgenic wheat whether the bad influences to humans heath had, the small white rats feeding transgenic wheat xi’nong1376 with P_SAG12-IPT gene and common wheat xi’nong1376 were studied separately. The haematology and biochemistry indexes, organic histological maps of liver, kidney, intestines, lung, cerebra and testicle of parents and baby generation rats of the two groups were analyzed. The results showed that every index of the two groups did not have significant difference. It indicted that transgenic wheat xi’nong1376 with P_SAG12-IPT gene did not have obviously bad influences to small white rats health and might be safety to human health.